Prehospital whole blood transfusion in hemorrhagic shock: A systematic review

Pierre-Marc Dion; Adam Greene; Theresa Aves; Andy Pan; Ian R. Drennan; Johannes von Vopelius-Feldt; Andrew Beckett; Risa Shorr; Brodie Nolan

doi:10.1111/trf.70146

March 7, 2026TransfusionOpen Access

Prehospital whole blood transfusion in hemorrhagic shock: A systematic review

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Key Points

The review aims to assess the safety and effectiveness of prehospital whole blood transfusion compared to component therapy or crystalloid resuscitation for adults with hemorrhagic shock.
Conducted a systematic review following PRISMA guidelines.
Included studies from various databases focusing on adults 16+ with hemorrhagic shock.
Evaluated outcomes including 24-hour all-cause mortality and transfusion-related adverse events.
Seven studies included, involving a total of 6954 patients.
Whole blood transfusion was associated with lower transfusion requirements compared to component therapy.
No increase in adverse transfusion reactions was reported in the whole blood group.

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Implication

This systematic review evaluates prehospital whole blood transfusion's effectiveness on survival in adults with hemorrhagic shock, indicating potential benefits.

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Cite This Study

Dion et al. (2026) studied this question.

synapsesocial.com/papers/69af947370916d39fea4b82d https://doi.org/10.1111/trf.70146

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Prehospital whole blood transfusion in hemorrhagic shock: A systematic review

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Prehospital whole blood transfusion in hemorrhagic shock: A systematic review

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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