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March 10, 2026Acta Ophthalmologica1 citationsOpen Access

Evaluation of Geographic Atrophy Progression Using Optical Coherence Tomography and Microperimetry

The optical coherence tomography and microperimetry biomarker evaluation in patients with geographic atrophy ( OMEGA ) study: Geographic atrophy progression in fundus autofluorescence ‐ OMEGA report 3

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Authors

PVPhilippe ValmaggiaGAGeorg AnsariNINadja Inglin

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Overview

Natural history study measures geographic atrophy progression in age-related macular degeneration, indicating multifactorial influences.

Key Points

  • This study aims to measure the progression of geographic atrophy in subjects with age-related macular degeneration.
  • Analyzed fundus autofluorescence images using a semiautomatic method (RegionFinder).
  • Scheduled patient visits at baseline, 12, 24, and 48 weeks.
  • Three independent graders assessed each eye's GA area.
  • Annual GA progression rate was 1.16 mm²/year (95% CI: 0.76–1.56; p < 0.001).
  • Faster progression observed in eyes with larger baseline lesions (R² = 0.74).
  • Significant associations found between larger GA lesions and smoking pack-years, hyperautofluorescence, and multifocal configuration.
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Cite This Study

Valmaggia et al. (2026) studied this question.

synapsesocial.com/papers/69af952b70916d39fea4c6a7https://doi.org/10.1111/aos.70119
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Monitoring of Geographic Atrophy Progression in Age-Related Macular Degeneration Using Fluorescence Lifetime Imaging Ophthalmoscopy.2026
  2. 2Monitoring of Geographic Atrophy Progression in Age-Related Macular Degeneration Using Fluorescence Lifetime Imaging Ophthalmoscopy2026
  3. 3[Progression assessment for geographic atrophy].2025
  4. 4Phenotypic characterization of predictors for development and progression of geographic atrophy using optical coherence tomography.2024 · 5 citations
  5. 5Long-Term Natural History of Treatment-Naïve Geographic Atrophy in Age-Related Macular Degeneration2025