Randomized trial examines fluorescence lifetime changes in geographic atrophy, indicating progression predictors in AMD.
Key Points
This research aims to analyze changes in fluorescence lifetime at the border zone of geographic atrophy due to age-related macular degeneration.
Included patients with geographic atrophy due to age-related macular degeneration.
Conducted imaging using fundus autofluorescence, optical coherence tomography, and fluorescence lifetime imaging at baseline and 5-year follow-up.
Measured geographic atrophy progression and fluorescence lifetime at five regions of interest.
Geographic atrophy area increased by an average of 1.21 mm2/year.
Fluorescence lifetime progressively decreased toward unaffected retina at each visit, with steeper gradient correlating with growth rate (P=0.02, r2=0.17).
Fluorescence lifetime gradient at the border zone was predictive of geographic atrophy progression rate.