Promoting clinical trials in pediatric IgA nephropathy through extrapolation: an artificial intelligence–enhanced literature review of the disease in pediatrics sponsored by the Kidney Health Initiative

Carmela Serpe; Eleanor M. Kerr; Cecile Fajardo; Barbara S. Gillespie; Sai Prasad N. Iyer; Myda Khalid; R. Komers; Koichi Nakanishi; Raoul D. Nelson; Jun Oh; Bonnie Schneider; Lokesh Shah; Nicholas J.A. Webb; Xuhui Zhong; Grace Squillaci; Mark David Lim; Howard Trachtman

doi:10.1007/s00467-026-07245-2

March 8, 2026Pediatric NephrologyOpen Access

Promoting clinical trials in pediatric IgA nephropathy through extrapolation: an artificial intelligence–enhanced literature review of the disease in pediatrics sponsored by the Kidney Health Initiative

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Key Points

The study aims to explore the potential for using extrapolation in designing clinical trials for pediatric IgA nephropathy based on adult data.
Conducted a literature review using artificial intelligence to analyze data on IgA nephropathy.
Identified similarities in the biological basis of the disease between pediatric and adult patients.
Findings suggest that extrapolation could inform trial design for pediatric IgA nephropathy.
The review indicates that adult data could be relevant for understanding pediatric cases.

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Implication

Literature review enhances the design of clinical trials in pediatric IgA nephropathy, indicating potential benefits of extrapolation.

Abstract

In conjunction with the similar biological basis of the disease in pediatric and adult patients, these findings may enable the use of extrapolation in the design of clinical trials in pediatric patients with IgAN.

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Serpe et al. (2026) studied this question.

synapsesocial.com/papers/69af952b70916d39fea4c785 https://doi.org/10.1007/s00467-026-07245-2

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Promoting clinical trials in pediatric IgA nephropathy through extrapolation: an artificial intelligence–enhanced literature review of the disease in pediatrics sponsored by the Kidney Health Initiative

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Promoting clinical trials in pediatric IgA nephropathy through extrapolation: an artificial intelligence–enhanced literature review of the disease in pediatrics sponsored by the Kidney Health Initiative

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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