A method demonstrates enantioselective α-oxidation of ketones, indicating potential for synthetic applications.
Development of new asymmetric radical reactions is of significant interest to the synthetic community. In this article, we describe a chiral Brønsted acid catalyzed enantioselective α‐oxidation of ketones carrying heteroaromatic templates using TEMPO and a metal oxidant. The methodology provides access to α‐aminoxylated ketones in high yields and good enantioselectivities.
No takes yet. Share an insight, caveat, or question.
Takeda et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: