Clinical Practice Guideline on the Choice of First Antipsychotic Medicine for Females Experiencing a First-Episode of Psychosis

Q: What does this research mean for the field?

This clinical practice guideline supports safer, sex-sensitive prescribing of antipsychotic medications for females experiencing a first episode of psychosis, potentially improving treatment acceptability and adherence. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

Caroline Hynes; Dolores Keating; Aoife Carolan; Bodyl Brand; Paola Dazzan; Fiona Gaughran; Margaret Hahn; Sean Halstead; Sophie Mae Harrington; Yvonne Hartnett; Ian Kelleher; John Lyne; Fiona McNicholas; Karen M. O’Connor; B. Perry; Ewa Sadowska; Brian O’Donoghue; Iris E Sommer

doi:10.1093/schbul/sbag023

Key Points

To develop a clinical practice guideline for selecting antipsychotic medications for females experiencing their first episode of psychosis.
Conducted a review of existing literature on antipsychotic choices for females
Emphasized patient outcomes and lived experiences in the guideline
Developed recommendations for safe, sex-sensitive prescribing practices
Introduced the first guideline tailored for females with first-episode psychosis
Highlighting the importance of treatment acceptability and adherence
Improved equity in psychosis care for females through targeted recommendations

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Implication

This guideline supports improved antipsychotic prescribing for females with first-episode psychosis, highlighting important patient outcomes.

Abstract

This is the first CPG addressing antipsychotic choice for females with FEP. By prioritizing critically important patient outcomes and lived experience, the guideline supports safer, sex-sensitive prescribing for females that may improve treatment acceptability, adherence, and equity in psychosis care.

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Cite This Study

Hynes et al. (2026) studied this question.

synapsesocial.com/papers/69af955970916d39fea4cc4f https://doi.org/10.1093/schbul/sbag023

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Clinical Practice Guideline on the Choice of First Antipsychotic Medicine for Females Experiencing a First-Episode of Psychosis

Key Points

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Implication

Abstract

Discussion

Cite This Study

Clinical Practice Guideline on the Choice of First Antipsychotic Medicine for Females Experiencing a First-Episode of Psychosis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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