Health-related quality of life in patients with vestibular schwannoma managed with observation, stereotactic radiosurgery or microsurgery: a systematic review and single-arm meta-analysis

March 1, 2026Journal of NeurologyOpen Access

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Key Points

To evaluate health-related quality of life in patients with vestibular schwannoma managed with different treatment strategies.
Systematic review of studies comparing health-related quality of life outcomes
Inclusion of patients managed by observation, stereotactic radiosurgery, or microsurgery
Use of PANQOL scores to assess quality of life
Single-arm meta-analysis to summarize findings
Patients report similar health-related quality of life across treatment modalities
Numerical differences in PANQOL scores were noted but deemed not clinically meaningful
Observed variability suggests a lack of standardized measures and national collaboration in treatment approaches

Systematic review assesses health-related quality of life in vestibular schwannoma patients, indicating need for improved decision-making standards.

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Pruijn et al. (2026) studied this question.

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