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March 10, 2026Journal of Neurology0 citationsOpen Access

Health-related quality of life in patients with vestibular schwannoma managed with observation, stereotactic radiosurgery or microsurgery: a systematic review and single-arm meta-analysis

IPIneke M. J. PruijnRadboud University Nijmegen FWFrédérique R. L. M. WelieRadboud University Nijmegen WKWietske Kievit

Key Points

To evaluate health-related quality of life in patients with vestibular schwannoma managed with different treatment strategies.
Systematic review of studies comparing health-related quality of life outcomes
Inclusion of patients managed by observation, stereotactic radiosurgery, or microsurgery
Use of PANQOL scores to assess quality of life
Single-arm meta-analysis to summarize findings
Patients report similar health-related quality of life across treatment modalities
Numerical differences in PANQOL scores were noted but deemed not clinically meaningful
Observed variability suggests a lack of standardized measures and national collaboration in treatment approaches

Abstract

Patients with unilateral VS report broadly comparable HRQoL following W&S, SRS, or MS. Although numerical differences in PANQOL scores exist, they are not clinically meaningful. The observed heterogeneity highlights the need for standardized, prospective studies and international collaboration to better inform patient-centered decision-making.

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