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This study investigates the antioxidant and cytotoxic properties of water extract from Annona muricata bark and the effects of different drying and maceration methods.

March 10, 2026Food Chemistry AdvancesOpen Access

Optimization of drying and maceration parameters on the antioxidant activity and toxicity of Annona muricata bark water extract

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BGBinawati Ginting MYMustanir Yahya NSNurdin SaidiUniversitas Syiah Kuala

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Research examines antioxidant and cytotoxic properties of Annona muricata bark extracts, suggesting potential in cancer therapy.

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This study investigates the antioxidant and cytotoxic properties of water extract from Annona muricata bark and the effects of different drying and maceration methods.
Explored various drying methods: air-drying, sun-drying, oven-drying, microwave-drying.
Varying maceration times of 1, 3, and 5 minutes used for extraction.
Antioxidant activity tested using DPPH method, Total Phenolic Content, and Total Flavonoid Content measures.
Cytotoxicity evaluated using the Brine Shrimp Lethality Test and MTT assay.
Oven-dried extract with 3 minutes of maceration had total phenolic content of 776 mg GAE/g.
Total flavonoid content recorded was 15.18 mg QE/g.
Antioxidant activity showed IC 50 value of 28.65 µg/mL, indicating very strong effects.
Cytotoxicity against MCF-7 cells had an IC 50 value of 2118.41 µg/mL, classified as inactive.
Toxicity measured by BSLT showed a high toxic LC 50 value of 68.49 µg/mL.

Cite This Study

Ginting et al. (2026) studied this question.

synapsesocial.com/papers/69af957570916d39fea4d061 https://doi.org/10.1016/j.focha.2026.101270

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Optimization of drying and maceration parameters on the antioxidant activity and toxicity of Annona muricata bark water extract

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Cite This Study

Optimization of drying and maceration parameters on the antioxidant activity and toxicity of Annona muricata bark water extract

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Key Points

Cite This Study

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