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March 10, 2026Clinical and Translational Discovery0 citationsOpen Access

From channel‐spatial attention to state space models: A review of evolving mechanisms in tumour segmentation

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YSYanfei SunYWYì WángRYRui Yin

Key Points

  • The review explores the progression and application of attention architectures in tumor segmentation.
  • Reviewed three paradigms: Pre-Transformer, Transformer-based self-attention, and Mamba-based state space models.
  • Analyzed functional roles from channel enhancement to long-range dependency modeling.
  • Assessed hybrid structures for multimodal clinical oncology.
  • Established attention mechanisms as crucial for intelligent segmentation tools.
  • Highlighted enhancements in feature localization and segmentation accuracy.
  • Identified future challenges and potential impacts on precision medicine.

Abstract

Abstract Objective This review delineates the evolution of attention architectures in automated tumor segmentation across three pivotal paradigms: classic Pre‐Transformer attention, dominant Transformer‐based self‐attention, and emerging Mamba‐based state space models. Methods We synthesize their functional roles—from channel enhancement to long‐range dependency modelingand critically assess hybrid structures designed for multimodal clinical oncology scenarios. Findings/Results The review establishes attention mechanisms as a foundational pillar for the next generation of intelligent segmentation tools, highlighting their potential in feature enhancement and localization. Conclusion Interrogating current challenges and charting future trajectories, these mechanisms are poised to profoundly impact the landscape of precision medicine.

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Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/69af959570916d39fea4d4ffhttps://doi.org/10.1002/ctd2.70127
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