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March 1, 2026Asian Pacific Journal of Cancer PreventionOpen Access

Mechanistic Exploration of the anticancer activity of Justicia adhatoda Plant Leaf Ethanolic Extract against Colon Cancer Cells: An in silico and in vitro Approach

Bhuvaneswari Ponnusamy Ponnulakshmi Rajagopal Chella Perumal Palanisamy Vishnu Priya Veeraraghavan Selvaraj Jayaraman

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Key Points

To explore the anticancer properties of Justicia adhatoda leaf ethanolic extract against colon cancer cells.
Conducted in vitro studies on HT-29 colon adenocarcinoma cells.
Utilized in silico modeling to assess mechanisms of action.
Analyzed the effects of ethanolic extract on cancer cell viability.
Ethanolic extract demonstrated significant anticancer activity.
HT-29 cell viability was reduced following treatment.
Potential mechanisms of action were suggested through in silico analysis.

Implication

In vitro and in silico analysis shows effective anticancer activity in HT-29 colon adenocarcinoma cells, implying potential treatment benefits.

Abstract

Overall, the findings suggest that JA ethanolic extract could be an effective anticancer agent against HT-29 colon adenocarcinoma cells.

Discussion

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Cite This Study

Ponnusamy et al. (2026) studied this question.

synapsesocial.com/papers/69af95a470916d39fea4d737 https://doi.org/10.31557/apjcp.2026.27.3.1069

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