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March 10, 2026LabMed discovery.Open Access

Reengineering immunotherapeutic responses: ferroptosis-primed radiotherapy converts cold-colorectal tumors into immunotherapy checkpoint inhibitor-sensitive hot lesions

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Authors

HJHang JiaSecond Military Medical UniversityLZLe-qi ZhouSecond Military Medical UniversityRWRong-bo WenSecond Military Medical University

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Implication

Research demonstrates a dual approach to enhance immunotherapy responsiveness in colorectal cancer, suggesting improved treatment outcomes.

Key Points

  • This research aims to explore how to make cold colorectal tumors more responsive to immunotherapy by using radiotherapy to induce ferroptosis.
  • Investigated the role of ferroptosis in immune cell recruitment post-radiotherapy.
  • Analyzed how extracellular glutathione peroxidase 4 affects dendritic cell maturation.
  • Proposed a dual strategy combining ferroptosis induction and inhibition of the eGPX4-ZP3 axis.
  • Ferroptosis induced by radiotherapy increases CD8 + T-cell recruitment and activity.
  • Extracellular glutathione peroxidase 4 inhibits dendritic cell maturation, limiting T-cell responses.
  • Dual strategy is suggested to improve immune response and overcome resistance in MSS colorectal cancer.

Cite This Study

Jia et al. (2026) studied this question.

synapsesocial.com/papers/69af95b470916d39fea4d937https://doi.org/10.1016/j.lmd.2026.100119
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