Plasma-activated hydrogel promotes postoperative colonic anastomotic leak healing

Xue Han; Kaijie Ren; Tianhao Min; Yuyi Ma; Yu-Ping Peng; Siyi Wang; Bo Zhang; Xin Xie; Yanglong Nan; Shiyao Tong; Ying Liu; Y J Zhang; Kang Li; Wei Wang; Nan Hao; Yili Wang; Chengxue Dang; Tuanhe Sun; Bo Ma; Hao Zhang

doi:10.1016/j.jare.2026.02.056

Key Points

To evaluate the efficacy of a plasma-activated hydrogel in healing colonic anastomotic leaks.
Used a rat model of colonic anastomosis.
Administered plasma-activated hydrogel at the surgical site.
Assessed healing outcomes based on anastomotic leak rates.
Hydrogel application showed reduced rates of anastomotic leaks.
Improved healing observed compared to controls.
Potential for clinical application in gastrointestinal surgeries.

Implication

Preclinical study demonstrates improved healing of anastomotic leaks in gastrointestinal surgery, indicating promising clinical applications.

Abstract

Hyd@CAP represents an emerging therapeutic strategy with potential applications in the management of AL following gastrointestinal surgery. Its efficacy has been preliminarily validated in a rat model of CAL, suggesting potential for early-phase clinical translation and possible extension to anastomotic repair throughout the entire gastrointestinal tract.

Discussion

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Cite This Study

Han et al. (2026) studied this question.

synapsesocial.com/papers/69af95cf70916d39fea4dc2b https://doi.org/10.1016/j.jare.2026.02.056

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Plasma-activated hydrogel promotes postoperative colonic anastomotic leak healing

Key Points

Implication

Abstract

Discussion

Cite This Study

Plasma-activated hydrogel promotes postoperative colonic anastomotic leak healing

Key Points

Implication

Abstract

Discussion

Cite This Study

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