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March 12, 2026BMC Infectious DiseasesOpen Access

Global prevalence of herpes simplex virus among pregnant women: a systematic review and meta-analysis

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Authors

ANAmin Shehni NezhadpourEHEmadeddin HemadiANArash Shehni Nezhadpour

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Overview

A systematic review reports HSV prevalence in pregnant women, suggesting limited utility for universal screening.

Key Points

  • The aim is to synthesize global HSV prevalence in pregnant women and assess clinical implications for management.
  • Systematic search of databases from 2000 to 2024 for observational HSV prevalence studies in pregnant women.
  • Data extraction and quality assessment were performed by independent reviewers.
  • Random-effects meta-analysis was conducted on logit-transformed proportions using Python libraries.
  • Meta-regression analyzed temporal trends in prevalence.
  • HSV-1 IgG seroprevalence was 79.1%, indicating widespread prior exposure among pregnant women.
  • HSV-2 IgG seroprevalence was 28.6% with significant geographic variation, ranging from 6% to 55%.
  • Acute infection markers (IgM) were rare: HSV-1 at 1.9% and HSV-2 at 4.7%.
  • PCR testing detected HSV DNA in 9.4% of cervico-vaginal samples, but 0% in amniotic fluid.

Cite This Study

Nezhadpour et al. (2026) studied this question.

synapsesocial.com/papers/69b2573196eeacc4fcec5d64https://doi.org/10.1186/s12879-026-12986-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Global Seroprevalence (HSV‐2 IgG), Risk Factors, and Outcomes of Genital Herpes Infection During Pregnancy: A Systematic Review and Meta‐Analysis2026
  2. 2Clinico-Microbiological Study of Herpes in Pregnant Females with Bad Obstetric History (BOH)2024
  3. 3Seroprevalence of Herpes simplex virus Type-1 IgG antibodies among pregnant women with recurrent abortions2024
  4. 4Seroprevalence of Herpes simplex virus Type-1 IgG antibodies among pregnant women with recurrent abortions2024
  5. 5Seroprevalence of Herpes Simplex Virus Types 1 and 2 among Pregnant Women in South-Western Romania2024 · 8 citations