Communication demonstrates the creation of irreversible covalent inhibitors targeting tyrosine and tryptophan, indicating a new approach in protein chemistry.
Expanding the covalent toolkit: Cyclic imine Mannich electrophiles enable covalent targeting of tyrosine and tryptophan residues. This artwork highlights the selectivity of this reaction over other protein functional groups. Krusemark and co-workers demonstrate the first use of this chemistry for creation of irreversible covalent inhibitors in the Communication (e16630).
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Wang et al. (2026) studied this question.
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