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Systematic review compares outcomes of enucleation and esophagectomy in esophageal GISTs, suggesting guide for treatment decisions.
Surgery remains curative for esophageal gastrointestinal stromal tumors (GISTs), while debates persist between minimally invasive enucleation and radical esophagectomy. Limited evidence from case reports and small cohorts necessitates a systematic evaluation to guide clinical decisions. This review showed that enucleation may be considered for small and low-mitotic-index esophageal GISTs with benign tendency. Despite higher R1 and tumor rupture rates, survival outcomes were comparable to esophagectomy. Enucleation, including endoscopic enucleation, was safe and effective in selected cases.
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Zhang et al. (2026) studied this question.
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