Research shows that enhanced plasticity worsens visual function in a mouse model of retinitis pigmentosa, indicating unexpected outcomes.
The RhoP23H/+ mouse model of RP displays progressive loss of visual acuity first under mesopic conditions and then under photopic conditions. The severity of acuity impairment correlates only broadly with deficits in retinal function measured with the ffERG but is consistent with the percentage of neurons in primary visual cortex responsive to higher spatial frequency visual stimuli measured with calcium imaging. Contrary to our hypothesis, enhancing neural plasticity is deleterious for visual function in RhoP23H/+ mice.
No takes yet. Share an insight, caveat, or question.
Attaway et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: