Observational study reveals distinct and shared brain connectivity alterations in subthreshold and major depression, suggesting implications for treatment.
Abnormal connectivity patterns of the SN and AN may contribute to the development of depressive symptoms in StD and MDD, while altered FC of the DMN may be involved in the onset of the disease. A social cognition deficit appeared first in StD, relating to the abnormal connectivity of the SN.
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Zhong et al. (2026) studied this question.
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