Modelling approaches for estimating vaccine effectiveness of consecutive SARS-CoV-2 variant sublineages in the absence of study-specific genetic sequencing data, VEBIS hospital network, Europe, 2023/24

Key Points

• This research aims to estimate vaccine effectiveness (VE) for consecutive SARS-CoV-2 variant sublineages without specific genetic sequencing data.
• Utilized two modeling approaches for VE estimation.
• Compared results with traditional VE estimation methods.
• Analyzed data from the VEBIS hospital network in Europe.
• Both modeling approaches yielded VE estimates comparable to established methods.
• The VPM approach provided valid VE estimates even with low sample sizes.