Radiomics-driven prediction of pathologic complete response in non-mass breast cancer using post-neoadjuvant chemotherapy preoperative dynamic contrast-enhanced magnetic resonance imaging

O. Moroz; Yang Liu; Cheng Liu; Qian Yin; XingRui Li; Tao Ai

doi:10.4274/dir.2026.263773

March 9, 2026Diagnostic and Interventional RadiologyOpen Access

Radiomics-driven prediction of pathologic complete response in non-mass breast cancer using post-neoadjuvant chemotherapy preoperative dynamic contrast-enhanced magnetic resonance imaging

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Key Points

The aim is to predict pathologic complete response (pCR) in non-mass breast cancer using radiomics from MRI images after neoadjuvant chemotherapy.
Developed a radiomics model based on dynamic contrast-enhanced MRI analysis.
Performed external validation of the model to confirm its accuracy.
Evaluated the predictive ability for identifying patients likely to benefit from neoadjuvant chemotherapy.
The radiomics model accurately predicts pCR in patients.
Successful external validation suggests the model is interpretable and reproducible.
The approach could help avoid ineffective treatments for non-responders.

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Implication

Radiomics model predicts pathologic complete response in non-mass breast cancer, suggesting improved treatment planning.

Abstract

Accurate early prediction of pCR could help identify patients most likely to benefit from NAC and avoid ineffective treatment in non-responders. The developed radiomics model offers an interpretable and reproducible tool; upon successful external validation, it has the potential to support personalized treatment planning in patients with NML-type breast cancer.

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Moroz et al. (2026) studied this question.

synapsesocial.com/papers/69b257af96eeacc4fcec6822 https://doi.org/10.4274/dir.2026.263773

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Radiomics-driven prediction of pathologic complete response in non-mass breast cancer using post-neoadjuvant chemotherapy preoperative dynamic contrast-enhanced magnetic resonance imaging

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Radiomics-driven prediction of pathologic complete response in non-mass breast cancer using post-neoadjuvant chemotherapy preoperative dynamic contrast-enhanced magnetic resonance imaging

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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