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March 12, 2026Chinese Journal of ChromatographyOpen Access

Analysis of urine biomarkers in urothelial carcinoma based on untargeted metabolomics

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Authors

SLSai LIUMWMo WANGWWWei long Wang

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Overview

Analysis uncovers urinary biomarkers in urothelial carcinoma, suggesting new diagnostic tools for cancer detection.

Key Points

  • The study aims to identify urinary biomarkers for urothelial carcinoma using untargeted metabolomics to aid in non-invasive diagnosis.
  • Collected urine specimens from 30 UC patients and 30 healthy controls
  • Employed untargeted metabolomic profiling using LC-MS/MS
  • Performed quality control and multivariate analyses to identify differential metabolites
  • Conducted pathway enrichment analysis for identified metabolites
  • Detected significant differences in urinary metabolites between UC patients and healthy controls
  • Identified alterations in metabolites associated with amino acid metabolism and nucleotide biosynthesis
  • Histidine metabolism pathway showed the highest impact in terms of differential alterations

Cite This Study

LIU et al. (2026) studied this question.

synapsesocial.com/papers/69b257cd96eeacc4fcec6c46https://doi.org/10.3724/sp.j.1123.2025.05018
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