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March 12, 2026Open Access

Data from the Swiss National Arthroplasty Registry SIRIS suggest that unicompartmental knee arthroplasty is associated with a lower risk of periprosthetic joint infection than total knee arthroplasty.

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Authors

PWPeter WahlCBChristian BrandBCBernhard Christen

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Overview

A retrospective analysis compares periprosthetic joint infection rates in unicompartmental knee arthroplasty versus total knee arthroplasty, suggesting implications for surgical approaches.

Key Points

  • This research aims to compare the rates of periprosthetic joint infection (PJI) and revision surgeries between unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA).
  • Conducted a retrospective analysis using data from the Swiss National Arthroplasty Registry (SIRIS) from 2012 to 2024.
  • Analyzed first revision rates after primary UKA or TKA for PJI and other causes.
  • Utilized Kaplan-Meier survival curves and calculated hazard ratios for statistical comparison.
  • Out of 35,286 primary UKA and 188,952 primary TKA, 149 revisions for PJI occurred in UKA and 1,546 in TKA.
  • The revision rate for any cause was higher for UKA (HR 1.29, p < 0.001) compared to TKA.
  • PJI-related revisions were significantly lower in UKA, with a rate of about half that of TKA (HR 0.53, p < 0.001).
  • Repeat revision rates after implant-retaining revision for PJI were higher for UKA, reaching 34.8% compared to 32.1% for TKA.

Cite This Study

Wahl et al. (2026) studied this question.

synapsesocial.com/papers/69b257df96eeacc4fcec6ed8https://doi.org/10.48620/95987
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Data from the Swiss National Arthroplasty Registry SIRIS suggest that unicompartmental knee arthroplasty is associated with a lower risk of periprosthetic joint infection than total knee arthroplasty2026
  2. 2FATE OF THE INFECTED UNICOMPARTMENTAL KNEE ARTHROPLASTY: A NEW ZEALAND JOINT REGISTRY STUDY2025
  3. 3Low implantation volume, comorbidities, male sex and implantation of constrained TKA identified as risk factors for septic revision in knee arthroplasty: A register‐based study from the German Arthroplasty Registry2024 · 13 citations
  4. 4Periprosthetic joint infection risk is comparable between unicompartmental knee arthroplasty to total knee arthroplasty conversion and primary total knee arthroplasty: A systematic review and meta‐analysis2025 · 1 citations
  5. 5Unicompartmental knee arthroplasty revisions to total knee arthroplasty2025 · 4 citations