Biological/targeted synthetic DMARDs do not arrest bone loss in patients with rheumatoid arthritis: a long‐term multicenter observational study

Q: What does this research mean for the field?

Biological/targeted synthetic DMARDs do not prevent bone loss in patients with rheumatoid arthritis, even when disease activity is controlled. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

Takafumi Aritomi; Koshiro Sonomoto; Shingo Nakayamada; Hiroaki Tanaka; Atsushi Nagayasu; Satoshi Kubo; Ippei Miyagawa; Ayako Yamaguchi; Naoaki Ohkubo; Yasuyuki Todoroki; Yurie Satoh‐Kanda; Masanobu Ueno; Ryuichiro Kanda; Yuya Fujita; Masashi Funada; Hidenori Sakai; Satsuki Matsunaga; Hiroaki Tanaka; Masayuki Shinojima; Hiroki Kawamura; Kazuki Takahashi; Miyabi Ando; Kazuki Haru; Yusuke Miyazaki; Kentaro Hanami; Masao Nawata; Shunsuke Fukuyo; Keisuke Nakatsuka; Mikiko Tokunaga; Kazuyoshi Saito; Yoshiya Tanaka

doi:10.1002/art.70125

Key Points

To investigate the effect of biological and targeted synthetic DMARDs on bone mineral density in rheumatoid arthritis patients.
Conducted a long-term multicenter observational study
Monitored rheumatoid arthritis activity and bone mineral density
Evaluated the relationship between b/tsDMARDs treatment and bone loss
Bone mineral density decreased despite controlled rheumatoid arthritis activity
Osteoporosis was identified as an important issue independent of inflammation control

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Long-term observational study finds biological DMARDs do not prevent bone loss in rheumatoid arthritis, suggesting a need for osteoporosis management.

Abstract

No abstract yet. The journal hasn't published one we can show.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Aritomi et al. (2026) studied this question.

synapsesocial.com/papers/69b257ec96eeacc4fcec7150 https://doi.org/10.1002/art.70125

View Full Paper

Ask AI

Bookmark

Share

Biological/targeted synthetic DMARDs do not arrest bone loss in patients with rheumatoid arthritis: a long‐term multicenter observational study

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Biological/targeted synthetic DMARDs do not arrest bone loss in patients with rheumatoid arthritis: a long‐term multicenter observational study

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading