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June 17, 2026Open Access Rheumatology Research and ReviewsOpen Access

Real-World Effectiveness of Biologic and Targeted Synthetic Therapies in Rheumatoid Arthritis: a Multicenter Study from Rheumatoid Arthritis Saudi Database (RASD)

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Authors

HAHani AlmoallimSBSami BahlasYBYasser Bawazir

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Overview

Multicenter cohort study analyzes treatment outcomes and persistence in rheumatoid arthritis therapies, indicating comparable effects.

Key Points

  • This research aims to compare the 12-month effectiveness and treatment persistence of biologic and targeted synthetic therapies in rheumatoid arthritis.
  • Conducted a prospective multicenter cohort study with RASD patients receiving advanced therapies.
  • Minimum follow-up of 12 months, with assessments at baseline, 3–6 months, and 12 months.
  • Used mixed-effects, covariate-adjusted regression, ordinal regression, logistic regression, and Kaplan-Meier methods for analysis.
  • Significant improvement in disease activity over time (p<0.0001), but no significant overall drug effect (p=0.327).
  • Comparable DAS28-CRP, CDAI, fatigue severity, and remission across therapies, with an adjusted OR of 2.45 for worse HAQ with certolizumab versus tofacitinib (95% CI 1.12–5.37).
  • Low discontinuation rates and no significant treatment persistence differences across therapies through 36 months (log-rank p=0.17).

Cite This Study

Almoallim et al. (2026) studied this question.

synapsesocial.com/papers/6a323d93d50b63ecad20737fhttps://doi.org/10.2147/oarrr.s613886
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