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March 12, 2026mSphere0 citationsOpen Access

mSphere of Influence: The power of in situ —structural biology without leaving “home”

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NWNicholas Wood

Key Points

  • This work reflects on the implications of using AlphaFold within the context of in situ structural biology.
  • Analyzing the capabilities of AlphaFold for predicting protein structures.
  • Discussing the limitations and open questions in structural biology.
  • Exploring cross-disciplinary training in microbiology.
  • Highlights the strengths of AlphaFold in modeling protein structures accurately.
  • Identifies limitations and challenges faced in structural biology today.
  • Suggests areas for further research and collaboration across disciplines.

Abstract

Nicholas A. Wood works in the field of biophysics with an emphasis on in situ protein structures in microbiological systems. In this mSphere of Influence article, he reflects on the power and limitations of AlphaFold, open questions in structural biology, and the cross-disciplinary potential of microbiological training.

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Cite This Study

Nicholas Wood (2026) studied this question.

synapsesocial.com/papers/69b2580996eeacc4fcec7469https://doi.org/10.1128/msphere.00798-25
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