Perspectives essay highlights the role of Hsp90 in rapid drug resistance evolution across fungal species, demonstrating the impact of molecular chaperones on biological complexity.
Linda Horianopoulos is a yeast biologist who uses a combination of comparative genomics, evolutionary analyses, and targeted molecular genetics to research the diversity of metabolism and stress responses across different yeast species. In this mSphere of Influence article, she highlights how a research article about Hsp90's ability to potentiate rapid evolution of drug resistance across different fungal species (https://doi.org/10.1126/science.1118370) influenced her work and the lens through which she appreciates biological complexity.
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Linda C. Horianopoulos (2026) studied this question.
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