Facile generation and reaction of densely trifluoromethylated alkyl radicals by dual photoredox and acid catalysis

Takashi Koike; Hina Taguchi; Kaori Hirota; Shota Kiyatake; Naohiro Tatara; Yoshihito Kayaki; Airi Yamaguchi; Tomoko Yajima

doi:10.1039/d6cc00475j

January 1, 2026Chemical Communications

Facile generation and reaction of densely trifluoromethylated alkyl radicals by dual photoredox and acid catalysis

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Key Points

This research aims to develop a straightforward method for generating densely trifluoromethylated alkyl radicals.
Utilized dual photoredox and acid catalysis for radical generation.
Employs readily available fluorinated alkyl benzoates as precursors.
Focused on the generation of the nonafluoro-tertbutyl radical.
Successfully generated densely trifluoromethylated alkyl radicals.
Demonstrated efficacy of the method with various fluorinated alkyl benzoates.
Highlighted applications in synthetic chemistry.

Implication

Method demonstrates generation of trifluoromethylated alkyl radicals, indicating new synthetic pathways.

Abstract

We have developed a simple method for generation of densely trifluoromethylated alkyl radicals, including the nonafluoro-tertbutyl radical. Readily available fluorinated alkyl benzoates derived from fluorinated alkyl alcohols act as radical...

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Cite This Study

Koike et al. (2026) studied this question.

synapsesocial.com/papers/69b2581996eeacc4fcec760d https://doi.org/10.1039/d6cc00475j

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Facile generation and reaction of densely trifluoromethylated alkyl radicals by dual photoredox and acid catalysis

Key Points

Implication

Abstract

Discussion

Cite This Study

Facile generation and reaction of densely trifluoromethylated alkyl radicals by dual photoredox and acid catalysis

Key Points

Implication

Abstract

Discussion

Cite This Study

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