Researchers uncover strategies to enhance treatment effectiveness for pancreatic cancer by targeting resistance mechanisms.
In PDAC, adaptive RAS-MAPK reactivation following KRASG12D inhibition can be mediated by different RTKs and influenced by cell state. Combinations of mutant-selective KRASi and RAS(ON) multi-selective inhibitors may represent a promising universal strategy to surmount adaptive resistance in PDAC patients.
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Lin et al. (2026) studied this question.
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