What question did this study set out to answer?

This study aims to explore the predictive value of NLR, PLR, RDW, and PDW on neonatal pneumonia outcomes.

March 12, 2026International Journal of General Medicine1 citationsOpen Access

Predictive Value of NLR, PLR, RDW and PDW in the Adverse Prognosis of Neonatal Pneumonia

XLXin LiuHebei Medical University YSYing ShenHebei Medical University YDYuqiao DiaoHebei Medical University

Key Points

This study aims to explore the predictive value of NLR, PLR, RDW, and PDW on neonatal pneumonia outcomes.
Retrospective analysis of 132 neonates with pneumonia and 50 healthy controls.
Evaluation of NLR, PLR, RDW, and PDW levels in relation to disease severity and prognosis.
Correlation analysis between blood markers and pneumonia severity.
Multivariate logistic regression to identify prognostic factors.
ROC curve analysis for predictive value assessment.
Significant differences in NLR, PLR, RDW, and PDW levels across different pneumonia severities (P< 0.05).
Positive correlation between NLR, PLR, RDW, PDW, and neonatal pneumonia severity (P< 0.05).
Combined predictive model shows 100% sensitivity and 94.9% specificity for adverse prognosis.

Abstract

Objective: Neutrophil-to-lymphocyte ratio (NLR), Platelet-to-lymphocyte ratio (PLR), Red-cell-distribution width (RDW) and Platelet-distribution width(PDW) have been proved to be related to the severity of a variety of diseases and poor prognosis. But their predictive value in neonatal pneumonia is still unknown. Therefore, this study explored the predictive value of NLR, PLR, RDW and PDW in the adverse prognosis of neonatal pneumonia. Methods: We retrospectively analyzed 132 neonates with pneumonia treated in our hospital from April 2022 to October 2024. At the same time, 50 healthy newborns delivered in our hospital during the same period were selected as the control group. The levels of NLR, PLR, RDW and PDW in children with different disease severity and prognosis were analyzed; The correlation between NLR, PLR, RDW, PDW levels and disease severity was analyzed, and the predictive value for the adverse prognosis of neonatal pneumonia. Results: Among 132 children, 65 were mild, 44 moderate and 23 severe; 26 cases had poor prognosis. The levels of NLR, PLR, RDW and PDW in children with different disease severity were significantly different (P< 0.05). Spearman test showed that NLR, PLR, RDW, PDW were significantly positively correlated with the severity of neonatal pneumonia (P< 0.05). Multivariate logistic regression analysis showed that NLR, PLR, RDW and PDW were the related factors influencing the poor prognosis of neonatal pneumonia (p< 0.05). ROC curve analysis showed that the value of combined prediction of four indicators for poor prognosis of neonatal pneumonia was higher than that of single indicators, and the sensitivity of combined prediction was 100%, and the specificity was 94.9%. Conclusion: NLR, PLR, RDW, PDW were positively correlated with the severity of neonatal pneumonia, and the value of combined prediction of poor prognosis was higher. Keywords: Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio, Red-cell-distribution width, Platelet-distribution width, neonatal pneumonia

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