Trifolium pratense L. Extract Improves Propofol-Induced Neuroprotection via Regulating GRP78/ ATF-6 and Bax-bcl2/p53 Signaling in Ischemic Brain Injury in Rats

Key Points

• The objective is to investigate how Trifolium pratense extract affects neuroprotection and the underlying molecular pathways in ischemic brain injury.
• Administered Trifolium pratense extract to rats with induced ischemic brain injury
• Measured the expression of GRP78, ATF-6, Bax, Bcl2, and p53
• Evaluated neuroprotective effects using propofol as a treatment approach
• Trifolium pratense extract significantly improved neuroprotection in rats
• Regulated key signaling molecules GRP78/ATF-6 and Bax/Bcl2/p53
• Showed enhanced brain function recovery post-ischemic injury