Palladium-Catalyzed Hydrofunctionalization Cyclization of 1,3-Enynes to Access Cyclopenta[b]indoles

Zonglin Ma; Xihang Lu; Hequan Yao; Aijun Lin

doi:10.1039/d6qo00090h

January 1, 2026Organic Chemistry FrontiersOpen Access

Palladium-Catalyzed Hydrofunctionalization Cyclization of 1,3-Enynes to Access Cyclopenta[b]indoles

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Key Points

This research aims to develop a new method for synthesizing cyclopenta[b]indoles using palladium catalysis.
Utilized palladium as a catalyst in the reaction process.
Applied sequential hydroarylation and hydroalkylation techniques.
Used readily available 1,3-enynes and indole-2-malonates for the synthesis.
Successfully synthesized cyclopenta[b]indoles through a redox-neutral approach.
Demonstrated an atom and step-economical synthesis route.

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Implication

Sequential hydroarylation and hydroalkylation synthesizes cyclopenta[b]indoles, suggesting an efficient method for complex molecule construction.

Abstract

We herein present a palladium-catalyzed sequential hydroarylation and hydroalkylation of readily available 1,3-enynes with indole-2-malonates. This redox-neutral strategy provides a facile, atom and step-economical route for the synthesis of cyclopenta[b]indoles...

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Ma et al. (2026) studied this question.

synapsesocial.com/papers/69b2583896eeacc4fcec79ad https://doi.org/10.1039/d6qo00090h

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Palladium-Catalyzed Hydrofunctionalization Cyclization of 1,3-Enynes to Access Cyclopenta[b]indoles

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Palladium-Catalyzed Hydrofunctionalization Cyclization of 1,3-Enynes to Access Cyclopenta[b]indoles

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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