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Analyses show that contraceptive drugs influence plasma cholesterol and triglycerides in rats, suggesting a need for monitoring lipoprotein levels before usage.
The effects of Microgynon, a combined oral contraceptive pill (0.15mg levonorgestrel and 0.03mg ethinylestradiol)and Primolut–N, a progestogen only pill (5mg norethisterone) were analysed for their in-vivo effects on rat (rattusrattus) plasma cholesterol and triglycerides. The drugs decreased plasma cholesterol levels in a concentrationdependent manner. Microgynon had the most effect, and a highest percentage decrease of 93.33% (0.002 ± 0.001mmol/l (P < 0.05)) was observed for the highest dose of 3.6μg/100g body wt. Primolut had lesser effects withfigures (0.008 ± 0.001 mmo/l and 0.009 ± 0.001mmol/l respectively). The drugs increased the levels of triglyceridewith Microgynon showing the highest value (0.114 ± 0.006 mmol/l).This result indicates that lipoprotein profile areneeded for women before using these drugs.
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Uwakwe et al. (2012) studied this question.
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