Key result
All five oral contraceptive preparations increase triglycerides, total cholesterol, and LDL-C, while HDL-C effects vary.
Why the study?
The effects of different oral contraceptive formulations on lipoprotein lipid levels in healthy young women were not fully characterized.
Do different oral contraceptive formulations differentially affect lipoprotein lipids in healthy young women?
RCT (n=169)
Randomly assigned
Do different oral contraceptive formulations differentially affect lipoprotein lipids in healthy young women?
Different oral contraceptive formulations uniformly increase triglycerides, total cholesterol, and LDL cholesterol, but have variable, dose-dependent effects on HDL cholesterol.
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Different OC formulations variably affect HDL; leaves open optimal selection for lipid profile in young women.
Powell et al. (1985) conducted an RCT in Healthy women (n=169). Oral contraceptives vs. Active comparators (different oral contraceptive preparations) was evaluated on Changes in lipoprotein lipids (total triglyceride, total cholesterol, LDL cholesterol, HDL cholesterol). All five oral contraceptive preparations caused statistically significant increases in total triglyceride, total cholesterol, and LDL cholesterol, while effects on HDL cholesterol varied by preparation.
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