What question did this study set out to answer?

This research aims to develop a new coupling strategy for synthesizing fully protected pyrophosphates using phosphorbromidate electrophiles.

March 12, 2026Chemical Science1 citationsOpen Access

Fully protected pyrophosphates via phosphorobromidates for the synthesis of biopolymers

SWSven WijngaardenLeiden University FHFemke L. A. M. van der HeijdenLeiden University KRKoen J. RijpkemaLeiden University

Puntos clave

This research aims to develop a new coupling strategy for synthesizing fully protected pyrophosphates using phosphorbromidate electrophiles.
Utilized P(v)–P(v) coupling strategy
Employed phosphorbromidate electrophiles
Implemented solid-phase synthesis methodology
Achieved synthesis of fully protected pyrophosphates
Enabled access to defined ADPr fragments of unprecedented length

Resumen

A P( v )–P( v ) coupling strategy using phosphorbromidate electrophiles, enables the solid-phase synthesis of fully protected pyrophosphates. This methodology provides synthetic access to defined ADPr fragments of unprecedented length.

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