Key result
Acridine orange detects early myocardial infarcts in sudden cardiac deaths with ~75% showing significant coronary stenosis.
Why the study?
To identify cases where an unnatural event, such as a road accident, is suspected to have been precipitated by acute myocardial ischemia, and to assess early infarct detection.
Does acridine orange fluorescence and H&E staining effectively detect early ischemic changes in post-mortem hearts of sudden cardiac death cases?
Population
100 hearts from autopsy cases suspected of acute myocardial ischemia
Comparison
Acridine orange fluorescent stain vs haematoxylin and eosin stain
Design
Histochemical post-mortem study
Authors
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Improves autopsy detection of early MI in SCD; supports acridine orange fluorescence as adjunct to H&E when standard histology is inconclusive.
Does acridine orange fluorescence and H&E staining effectively detect early ischemic changes in post-mortem hearts of sudden cardiac death cases?
Acridine orange fluorescence is an effective early detector of myocardial infarction in post-mortem cases of sudden cardiac death, identifying infarcts as early as 2 hours old.
Gohel et al. (2012) studied this question. Acridine orange detected early myocardial infarcts in sudden cardiac death cases, with 75% showing grade 2-3 coronary artery stenosis, predominantly in middle-aged males.
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