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Cohort study examines delayed therapeutic hypothermia effects on outcomes in neonates, suggesting it may be beneficial despite initiation challenges.
In this cohort, initiation of therapeutic hypothermia between 6 and 12 h after birth was not significantly associated with worse neurological or mortality outcomes than initiation within 6 h. These findings suggest that delayed therapeutic hypothermia may still confer benefits in settings where early initiation is challenging, underscoring the need to strengthen referral systems and further investigate the optimal therapeutic window.
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Agudelo-Pérez et al. (2026) studied this question.
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