Studies on Ethanolic Leaf Extract of Phyllanthus Niruri and Its Effect on Aflatoxin Intoxicated Male Albino Rats

Aflatoxin is an environmental toxicant which frequently contaminates foodstuffs in different parts of the world. The present investigation was an attempt to evaluate the possible ameliorative effects of Phyllanthus niruri on aflatoxins induced serological and biochemical changes in liver of rats. In the current study, toxicity was developed by oral administration of aflatoxin at a dose of (200 µg/kg body weight) for 40 days in male rats. P. niruri (300 mg/kg body weight) was given simultaneously for 40 days. Administration of P. s. niruri lowered the level of lipid peroxidation and enhanced the antioxidant status of animal. It can be concluded that the P. niruri acts as an effective drugs playing an important role in reduction of hepatotoxicity. In conclusion, Phyllanthus niruri was found to be safe and successful agent counteracting the aflatoxins toxicity and protected against the toxicity induced by aflatoxin. However, it suggests that a dose adjustment may be necessary to optimize the effects in clinical settings.