Metabolomic Profiling of Fecal Samples Reveals Distinct Signatures Associated with Disease Phenotypes and Locations in Crohn’s Disease

Q: What does this research mean for the field?

Distinct metabolomic signatures in fecal samples are associated with different phenotypes and disease activity in Crohn's Disease. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Tingyi Tan; Matthew Vincent; Umang Jain; Parakkal Deepak; SPARC I. B. D. Investigators; Richa Shukla; Themistocles Dassopoulos; Josh Korzenik; Scott B. Snapper; Satya Kudara; Laura Raffals; Manreet Kaur; Poonam Beniwal-Patel; Ray Cross; David Hudesman; Mazer Ally; Gauree G. Konijeti; Rebecca Matro; Kirk Russ; Kara De Felice; Joel Pekow; Sushila Dalal; Sheldon Lidofsky; Lauren George; Shrinivas Bishu; Meenakshi Bewtra; James A. Lewis; Richard H. Duerr; Sumona Saha; Freddy Caldera; Elizabeth Scoville

doi:10.1007/s10620-026-09779-9

Key Points

The aim is to identify metabolomic differences related to Crohn’s disease phenotypes and activity levels.
Conducted metabolomic profiling of fecal samples
Analyzed differences based on disease phenotypes and activity
Assessed potential as noninvasive biomarkers for patient stratification
Identified distinct metabolomic signatures tied to disease phenotypes
Demonstrated variations in metabolomics correlated with disease activity
Highlighted potential for using metabolites as biomarkers for guiding management

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Implication

Reveals metabolomic differences in Crohn’s disease, suggesting potential biomarkers for risk stratification and management.

Abstract

This study reveals metabolomic differences across CD phenotypes and disease activity, providing potential noninvasive biomarkers to help risk-stratify patients for complications and guide tailored management. Further validation in larger cohorts is warranted.

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Cite This Study

Tan et al. (2026) studied this question.

synapsesocial.com/papers/69b2587296eeacc4fcec8160 https://doi.org/10.1007/s10620-026-09779-9

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Metabolomic Profiling of Fecal Samples Reveals Distinct Signatures Associated with Disease Phenotypes and Locations in Crohn’s Disease

Key Points

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Implication

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Discussion

Cite This Study

Metabolomic Profiling of Fecal Samples Reveals Distinct Signatures Associated with Disease Phenotypes and Locations in Crohn’s Disease

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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