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March 12, 20260 citations

Precision dosing of clozapine: A physiologically based pharmacokinetic/pharmacodynamic model integrating genetic polymorphisms and clinical outcomes.

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GMGauravi MishraHomi Bhabha National InstituteASAnand SrinivasanAll India Institute of Medical Sciences BhubaneswarRMRituparna MaitiAll India Institute of Medical Sciences Bhubaneswar

Key Points

  • The aim is to develop a model for precision dosing of clozapine using genetic polymorphisms to enhance therapy outcomes.
  • Developed a physiologically based pharmacokinetic/pharmacodynamic model
  • Integrated genetic polymorphism data
  • Applied therapeutic drug monitoring principles
  • Model supports genotype-guided dosing of clozapine
  • Offers a framework for optimizing treatment efficacy
  • Enhances patient safety through individualized therapy

Abstract

This PBPK/PD model provides a robust framework for precision clozapine therapy, supporting genotype-guided dosing and TDM to optimize efficacy and safety. The implementation of pharmacogenetic testing could transform clinical practice, offering a framework for optimized resource utilization and risk minimization.

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Cite This Study

Mishra et al. (2026) studied this question.

synapsesocial.com/papers/69b2588496eeacc4fcec8450https://doi.org/10.1177/02698811261424205
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