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This modeling study demonstrates optimized clozapine therapy using genetic testing in clinical practice, suggesting improved resource use and risk reduction.
This PBPK/PD model provides a robust framework for precision clozapine therapy, supporting genotype-guided dosing and TDM to optimize efficacy and safety. The implementation of pharmacogenetic testing could transform clinical practice, offering a framework for optimized resource utilization and risk minimization.
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Mishra et al. (2026) studied this question.
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