What does this research mean for the field?

Core needle biopsy (CNB) demonstrates significantly greater diagnostic accuracy than fine-needle aspiration (FNA) for detecting malignant cervical lymphadenopathy without increased complication risk. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

The research aims to compare the diagnostic accuracy and safety of fine-needle aspiration (FNA) versus core needle biopsy (CNB) for cervical lymphadenopathy.

March 12, 2026OTO OpenOpen Access

Fine‐Needle Aspiration Versus Core Needle Biopsy for Malignant Cervical Lymphadenopathy: A Meta‐Analysis and Systematic Review

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Authors

SMSacha MoufarrejUC San Diego Health System KBKavenpreet BalKaiser Permanente ARAlexander RiveroKaiser Permanente Oakland Medical Center

Discussion

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Implication

Meta-analysis compares diagnostic effectiveness of FNA and CNB in cervical lymphadenopathy, suggesting CNB may be preferred.

Key Points

The research aims to compare the diagnostic accuracy and safety of fine-needle aspiration (FNA) versus core needle biopsy (CNB) for cervical lymphadenopathy.
Systematic review of studies published from 1995 to 2025
Comparison of diagnostic performance metrics for FNA and CNB
Meta-analysis conducted using a random-effects model
Quality assessment performed using QUADAS-2 criteria
Pooled sensitivity for CNB was 0.94, while FNA's was 0.72
Pooled specificity for CNB was 0.98, compared to FNA's 0.96
CNB showed 1.32 times greater sensitivity than FNA in detecting malignancy
Both techniques had low complication rates
Study heterogeneity was low to moderate with moderate risk of bias

Cite This Study

Moufarrej et al. (2026) studied this question.

synapsesocial.com/papers/69b2589696eeacc4fcec8531 https://doi.org/10.1002/oto2.70218

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Fine‐Needle Aspiration Versus Core Needle Biopsy for Malignant Cervical Lymphadenopathy: A Meta‐Analysis and Systematic Review

Discussion

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Implication

Key Points

Cite This Study

Fine‐Needle Aspiration Versus Core Needle Biopsy for Malignant Cervical Lymphadenopathy: A Meta‐Analysis and Systematic Review

Discussion

Member takes

Implication

Key Points

Cite This Study

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