What does this research mean for the field?

Salivary cortisol (CORT) is a practical biomarker for non-invasive monitoring of stress in first responders, while salivary C-reactive protein (CRP) and interleukin-6 (IL-6) require further validation as substitutes for blood biomarkers. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The research aims to validate non-invasive assessments of physiological stress and inflammation among first responders.

March 12, 2026Journal of Occupational and Environmental Medicine

Validation of A Non-Invasive Physiological Stress and Inflammatory Assessment: Agreement of Salivary and Blood Biomarkers Among First Responders

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The research aims to validate non-invasive assessments of physiological stress and inflammation among first responders.
Compared salivary and blood biomarkers of stress and inflammation among first responders.
Focused on salivary cortisol, CRP, and IL-6 levels.
Evaluated the practicality of using salivary samples in operational settings.
Salivary cortisol showed practicality for non-invasive monitoring.
Caution is advised regarding the use of salivary CRP and IL-6 as substitutes for blood measures.
Further research is necessary to confirm the reliability of salivary CRP and IL-6.

Implication

Validation assesses biomarkers for physiological stress in first responders, indicating salivary cortisol's practicality.

Abstract

Overall, while salivary CORT is practical for non-invasive monitoring in operational settings, caution is warranted with salivary CRP and IL-6, which need further research as blood substitutes.

Discussion

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Cite This Study

Gonzalez et al. (2026) studied this question.

synapsesocial.com/papers/69b2589696eeacc4fcec85a2 https://doi.org/10.1097/jom.0000000000003704

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Implication

Validation assesses biomarkers for physiological stress in first responders, indicating salivary cortisol's practicality.

Abstract

Overall, while salivary CORT is practical for non-invasive monitoring in operational settings, caution is warranted with salivary CRP and IL-6, which need further research as blood substitutes.

Validation of A Non-Invasive Physiological Stress and Inflammatory Assessment: Agreement of Salivary and Blood Biomarkers Among First Responders

Key Points

Implication

Abstract

Discussion

Cite This Study

Validation of A Non-Invasive Physiological Stress and Inflammatory Assessment: Agreement of Salivary and Blood Biomarkers Among First Responders

Key Points

Implication

Abstract

Discussion

Cite This Study

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