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March 12, 2026International Journal of Molecular SciencesOpen Access

Engineering Epitope-Specific IgY Antibodies to Neutralize the Major Fel d 1 Allergen in Cats

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Authors

XTXin TianTianjin UniversityCLChunxiao LiHenan UniversityWAWei AnChinese Academy of Agricultural Sciences

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Implication

Demonstrates a novel IgY antibody strategy to reduce Fel d 1 allergen levels in cats, suggesting a new approach for allergy treatment.

Key Points

  • The aim is to develop epitope-specific IgY antibodies to neutralize the Fel d 1 allergen in cats, improving allergy management.
  • Predicted T-cell epitopes of Fel d 1 using ProPred/CTLpred.
  • Expressed recombinant cFel d 1 in E. coli.
  • Immunized mice and hens, measuring high-titer IgG and IgY antibodies.
  • Administered anti-cFel d 1 IgY-enriched yolk powder to cats for four weeks.
  • Mice and hens produced high-titer specific antibodies (IgG: 1:301,500; IgY: 1:4,194,304).
  • Cats fed with 1-3% IgY yolk powder showed a 30-71% reduction in salivary Fel d 1 levels.

Cite This Study

Tian et al. (2026) studied this question.

synapsesocial.com/papers/69b258a396eeacc4fcec8813https://doi.org/10.3390/ijms27052500
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