Key result
AV node ablation carries a ~30% long-term rate of composite safety events.
Why the study?
Pharmacologic strategies often fail to achieve effective rate control in atrial arrhythmias, necessitating evaluation of long-term outcomes after atrioventricular node ablation.
Does radiofrequency atrioventricular node ablation provide safe and effective rate control in patients with symptomatic atrial arrhythmias refractory to pharmacologic therapy?
Observational (n=192)
Does radiofrequency atrioventricular node ablation provide safe and effective rate control in patients with symptomatic atrial arrhythmias refractory to pharmacologic therapy?
Atrioventricular node ablation is a highly effective procedure for restoring rate control and improving quality of life in refractory atrial arrhythmias, though baseline left ventricular dysfunction is strongly associated with subsequent heart failure hospitalization.
Supports AVNA for refractory arrhythmias with durable success and QoL gains; extends observational data but leaves long-term safety open.
BACKGROUND: While interventional strategies have expanded the options for long term rhythm restoration, rate control continues to play a pivotal role in the treatment of atrial arrhythmias; however, pharmacologic strategies alone often fail in achieving effective rate control. AIMS: To examine long-term outcomes in patients who have undergone atrioventricular node ablation (AVNA) for the management of symptomatic atrial arrhythmias. METHODS: This observational Study Assessed Patients Who Underwent AVNA For Rate Control of Atrial Fibrillation (AF) Or Atrial Tachycardia (AT) Between April 2014 and February 2022. Clinical data, along with follow-up information including cardiac device interrogation were analyzed. A composite safety endpoint, Encompassing Heart Failure (HF) Rehospitalization, lead revision, device infection, or upgrade for cardiac resynchronization therapy (CRT), was evaluated. Additionally, structured patient interviews were conducted to assess quality of life outcomes. RESULTS: 192 patients (76 females (39.6%), mean age 73.7 ± 10 years) were included into the study. Patients suffered from paroxysmal AF in 10 cases (5.2%), persistent AF in 138 cases (71.9%) and AT in 44 cases (22.9%). Acute AVNA was successful in all patients. Two pseudoaneurysms at the femoral puncture site occurred as the only periprocedural complications. Mean follow-up duration was 907.0 ± 609.7 days. Persistent complete AV block was present in 191 patients (99.5%) during follow-up. The composite safety endpoint occurred in 58 (30.2%) patients. Quality of life significantly improved in most patients with a relevant regression in EHRA and NYHA scores. CONCLUSION: AVNA is effective and safe in an all-comer patient population with high success rates in terms of rate control, QOL improvement and a favorable safety profile during long-term observation.
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Sciacca et al. (2026) conducted an observational in Atrial fibrillation or atrial tachycardia refractory to pharmacologic rate control (n=192). Atrioventricular node ablation was evaluated on Composite safety endpoint comprising rehospitalization for heart failure (HF), lead revision, device infection, or upgrade to cardiac resynchronization therapy (CRT). Atrioventricular node ablation in patients with refractory atrial arrhythmias resulted in persistent complete heart block in 99.5% and a 30.2% incidence of the composite safety endpoint over 907 days.
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