Phenotypic stratification reveals distinct metabolic profiles in Zucker diabetic fatty rats, suggesting personalized therapeutic approaches.
Under identical genetic and environmental conditions, ZDF (fa/fa) rats develop distinct metabolic phenotypes encompassing euglycemic obesity, pre-cachectic diabetes, and advanced cachectic diabetes. Phenotypic stratification is essential for accurate interpretation of ZDF experimental data and underscores the importance of characterizing individual metabolic trajectories when diabetic complications and therapeutic interventions are assessed in this model.
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Lepáček et al. (2026) studied this question.
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