Research finds Enterococcus faecalis adapts its metabolism and forms microcolonies in human colonic organoids, suggesting implications for gut health.
Gut microbiota interactions with mucus during early intestinal colonization are critical for establishing stable communities and influencing host health. Using human colonic organoids combined with Tn-seq and live imaging, this study reveals how Enterococcus faecalis adapts to the mucosal surface by forming microcolonies and reprogramming its metabolism. This integrative approach provides a powerful platform to study other microbiota members in the native-like environment of the large intestine and evaluate potential therapeutic interventions.
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Mikhaleva et al. (2026) studied this question.
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