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March 9, 2026Radiation Oncology JournalOpen Access

An insight into the pharmacoeconomics of carbon ion radiotherapy: a systematic review

Poovizhi Bharathi R Athiyamaan Mariappan Senthiappan Priyanka Madhav Kamath

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Key Points

The study evaluates the cost-effectiveness of carbon ion radiotherapy (CIRT) for multiple cancer types.
Systematic review of nine studies
Assessment of cost-effectiveness across various cancers
Consideration of real-world clinical practice implications
CIRT is found to be cost-effective in several cancer types including NSCLC and hepatocellular carcinoma.
Improved efficacy and reduced toxicity associated with CIRT enhance its cost-effectiveness.
Cost reductions and lower fractionation may further improve outcomes in clinical settings.

Implication

Systematic review examines cost-effectiveness of carbon ion radiotherapy across various cancers, suggesting improved outcomes in clinical practice.

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Cite This Study

R et al. (2026) studied this question.

synapsesocial.com/papers/69b25adb96eeacc4fcec8ff8 https://doi.org/10.3857/roj.2025.00696

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/RepairReview · 2017 · 200 citations
2Carbon-Ion radiotherapy alone for inoperable locally advanced Non-Small cell lung cancer: A Japanese National registry study (J-CROS-LUNG)Original Research · 2026 · 2 citations
3Carbon ion radiotherapy of hepatocellular carcinoma provides excellent local control: The prospective phase I PROMETHEUS trial2024 · 9 citations
4Dose-averaged LET optimized carbon-ion radiotherapy for head and neck cancers2024 · 21 citations
5Clinical Outcomes of Dual-Beam Particle Therapy in Head and Neck Adenoid Cystic CarcinomaOriginal Research · 2026 · 1 citations

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Carbon-ion radiotherapy achieves outcomes equivalent to surgical resection for hepatocellular carcinoma2025
Long-Term Outcomes of Ablative Carbon-Ion Radiotherapy for Central Non-Small Cell Lung Cancer: A Single-Center, Retrospective Study2024
Carbon-ion Radiotherapy for Inoperable Head and Neck Bone and Soft-tissue Sarcoma: Prospective Observational Study2022

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