Overexpression of Circ_0004496 is Associated with Pathological Bone Formation in Ankylosing Spondylitis via the miR-145/ACTG1 Axis.

March 10, 2026

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Key Points

Investigate the role of circ_0004496 in bone formation processes associated with ankylosing spondylitis.
Conducted in vitro experiments to assess the impact of circ_0004496 on cellular functions.
Performed in vivo studies to observe bone formation changes in model organisms.
Analyzed the relationship between circ_0004496, miR-145, and ACTG1 levels.
Circ_0004496 is significantly overexpressed in ankylosing spondylitis subjects.
Its overexpression correlates with increased pathological bone formation.
The miR-145/ACTG1 axis is identified as a critical regulatory pathway in these processes.

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Research demonstrates circ_0004496 overexpression promotes bone formation in ankylosing spondylitis, indicating important regulatory mechanisms.

Circ_0004496 overexpression promotes pathological bone formation in AS by regulating the miR-145/ACTG1 axis both in vitro and in vivo.

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Zou et al. (2026) studied this question.

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