Key result
Circular RNAs regulate atherosclerosis progression via miRNA sponging, offering potential diagnostic and therapeutic targets.
Why the study?
Abnormal expression and sponging effects of circRNAs on miRNAs are closely related to atherosclerosis development through epigenetic gene regulation changes.
CircRNAs are emerging as important epigenetic regulators and potential biomarkers or therapeutic targets in atherosclerosis.
Answers are grounded in this paper and cite their sources.
circRNA dysregulation in AS may influence progression; leaves open therapeutic targeting pending validation studies.
Atherosclerosis (AS) is a chronic inflammatory disease, which leads to atherosclerotic rupture, lumen stenosis and thrombosis, and often endangers life. Circular RNAs (circRNAs) are a special class of non-coding RNA molecules, whose abnormal expression has been proved to be closely related to human diseases, including AS. Both the abnormal regulation of circRNAs and the sponging effect on miRNAs would lead to changes in gene expression in the form of epigenetic modification, ultimately leading to the formation of AS. CircRNAs can be used as peripheral blood markers of AS, and play an important regulatory role in the proliferation, migration, inflammation and apoptosis of vascular smooth muscle cells, endothelial cells and macrophage, which are key cells for the development of AS. The in-depth understanding of circRNAs in AS not only provides a new method for the diagnosis of AS, but also provides a new idea for the treatment of AS.
No takes yet. Share an insight, caveat, or question.
Cheng et al. (2022) conducted a review in Atherosclerosis. Circular RNAs (circRNAs) was evaluated. Circular RNAs regulate gene expression in atherosclerosis via epigenetic modification and miRNA sponging, serving as potential diagnostic markers and therapeutic targets.
Synapse has enriched 10 related papers. Consider them for comparative context: