Key result
Extracellular vesicle-delivered circular RNAs drive atherosclerosis progression and offer potential as novel biomarkers and therapies.
Why the study?
Extracellular vesicle cargo circular RNAs are involved in atherosclerosis, motivating a summary of current data to elucidate their emerging roles, mechanisms, and potential as diagnostic biomarkers and novel therapeutics.
Extracellular vesicle-derived circular RNAs play a critical role in the progression of atherosclerosis and its risk factors, offering potential as future diagnostic and therapeutic targets.
EV-circRNAs merit study as atherosclerosis biomarkers and targets; leaves open clinical translation pending prospective validation.
Atherosclerosis (AS) is universally defined as chronic vascular inflammation induced by dyslipidaemia, obesity, hypertension, diabetes and other risk factors. Extracellular vesicles as information transmitters regulate intracellular interactions and their important cargo circular RNAs are involved in the pathological process of AS. In this review, we summarize the current data to elucidate the emerging roles of extracellular vesicle-derived circular RNAs (EV-circRNAs) in AS and the mechanism by which EV-circRNAs affect the development of AS. Additionally, we discuss their vital role in the progression from risk factors to AS and highlight their great potential for use as diagnostic biomarkers of and novel therapeutic strategies for AS.
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Wen et al. (2022) conducted a review in Atherosclerosis. Extracellular vesicle-delivered circular RNAs (EV-circRNAs) was evaluated. Extracellular vesicle-delivered circular RNAs play vital roles in the progression from risk factors to atherosclerosis and have great potential as diagnostic biomarkers and novel therapeutic strategies.
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