Key result
CircRNAs influence atherosclerosis pathogenesis via endothelial injury, VSMC transformation, and macrophage behavior.
Why the study?
Atherosclerosis remains a leading cause of cardiovascular mortality, and circular RNAs have gained attention for their unique role in its pathogenesis involving endothelial cells, vascular smooth muscle cells, and macrophages.
This review highlights the emerging mechanistic role of circular RNAs in atherosclerosis, providing potential new targets for prevention and treatment.
circRNA modulation remains investigational in atherosclerosis; extends mechanistic insights but leaves open clinical translation.
Cardiovascular diseases (CVDs) based on atherosclerosis remain the main reason for death in Western countries and China. Cardiovascular research has demonstrated that its pathogenesis is closely associated with endothelial cell (EC) injury, the phenotypic transformation of vascular smooth muscle cells (VSMCs), and the abnormal biological behaviour of macrophages. In recent years, circular RNAs (circRNAs) have received much attention for their unique role in the pathogenesis of atherosclerosis. In this review, we discussed the mechanisms associated with ECs, VSMCs, and macrophages in atherosclerosis and summarized the role of circRNAs in atherosclerosis. This review aims to provide a basis for the prevention and treatment of atherosclerosis.
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Yang et al. (2023) conducted a review in Atherosclerosis. Circular RNAs (circRNAs) was evaluated. Circular RNAs (circRNAs) play a unique role in the pathogenesis of atherosclerosis by influencing endothelial cell injury, vascular smooth muscle cell transformation, and macrophage behavior.
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