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A copper-catalyzed protocol demonstrates high diastereoselectivity in chiral biaryl synthesis, indicating broad functional group compatibility.
We report a copper-catalyzed Friedel-Crafts biarylation protocol that delivers C3-site-selective doubly axially chiral biaryl indoles using five-membered cyclic diaryliodonium salts as biarylating agents. This atom-economical and highly diastereoselective protocol delivers a diverse library of biaryl indoles, accommodating a broad range of functional groups in good to excellent yields. Additionally, successful reaction scale-up execution and the efficient synthesis of 9H-dibenzo[a,c]carbazole further highlight the practicality of the developed protocol.
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Banerjee et al. (2026) studied this question.
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